Loss-of-function mutations in the PINK1 or parkin genes result in recessive heritable forms of parkinsonism.Genetic studies of Drosophila orthologs of PINK1 and parkin indicate that PINK1, a mitochondrially targeted serine/threonine kinase, acts upstream of Parkin, a cytosolic ubiquitin-protein ligase, to promote mitochondrial fragmentation, althou
The current interventions for hepatocellular carcinoma (HCC) are not satisfactory, and more precise targets and promising strategies need to be explored.Recent research has demonstrated the non-negligible roles of RNA epigenetic modifications such as N6-methyladenosine (m6A) and 5-methylcytosine (m5C) in various cancers, including HCC.However, the
Neonatal testicular torsion is a critical urological emergency that poses a unique diagnostic challenge.It needs a high index of suspicion in a neonate with vague symptoms.It is characterized by the axial rotation of spermatic cord structures, which results in interruption of blood supply to the testicle.The duration of symptoms and degree of twist
The vertebrate Kindlins are an evolutionarily conserved family of proteins critical for Motor Carbon Brushes integrin signalling and cell adhesion.Kindlin-2 (KIND2) is associated with intercalated discs in mice, suggesting a role in cardiac syncytium development; however, deficiency of Kind2 leads to embryonic lethality.Morpholino knock-down of Kin
ObjectiveThis study aimed to analyze the relationship between the rate of morphological changes and intracranial aneurysm rupture during the cardiac cycle.MethodsEighty-four patients with intracranial aneurysms were retrospectively Outdoor Swivel Chair w/Cushion (set of 2) analyzed and divided into the rupture (42 cases) and unruptured (42 cases) g